Hypothalamus--> releases CRH hormone
Anterior pithutiary--- ACTH hormone
Zona fasciculata zone of the adrenal glands' cortex (inside is the medula).
Function of cortisone: resembles goals of Growth H and Thyroid H, but with a different.. feeds a tissue... energy feeding-- the brain ( to think neurones need energy) The brain relies on glucose not on fatty acids preferentially. If we are in a stress response... we need glucose, and we want the other tissues to (glucose sparing effect) use fatty acids mainly... sparing
Starts like other hormes
adipose tissue--> cortisol increase lipolysis (ie fatty acid supply in the blood).
In the Liver is stimulates Gluconeogeneis. Liver dumps the glucose in the blood.
Stimulates glucogeneolysis.. glycogen broken in individual glycogen peices in the blood..
---> increase both fatty acids + glucose in the blood (like tyhroid H + GH).. but then it diverges..
Break down the muscle protein...
decrease in glucose metabolism...
ATP: fat oxydation and amino oxydation... inhibits protein synthesis... (requires massive amount ATP and will be used for stress calm down)... protein degradation-- amino acid in the bloods increase (extra hepatic tissues)..
Well with Cushing u got chronic elevated cortisol so u end up having high blood sugar and elevated fatty acids but neither the brain nor the skeleton muscles need the energy so it gets stored in glycogen and abdominal fat again. Meanwhile due to the reduced anabolic metabolism in the muscles u lose muscle substance leading to the classic small extremities and fat torso, neck and face.